EFFECTS OF GFC ON SCARS AND DERMAL AUGMENTATION

Jan, 23 2023

EFFECTS OF GFC ON SCARS AND DERMAL AUGMENTATION

GFC IN FAT GRAFT 

GFC has a high concentration of growth factors e.g., PDGF, EDGF, VEGF, etc. with neovascularization properties, epithelial (skin) regeneration properties and, thus has the potential to promote the growth of healthy skin. Fat graft volume and weight were found to be significantly higher in the GFC. Histologic evaluation showed greater vascularity, fewer cysts and vacuoles, and lesser fibrosis in the GFC group. 

POST - ACNE ATROPHIC SCARS

GFC injections combined with acne lasers provide good results in the treatment of acne scars. 

Our experience 

We find the combination of GFC therapy with laser resurfacing to be an effective therapeutic modality for the treatment of post-acne atrophic scars. This combination also helps in decreasing the downtime and incidence of adverse effects like post-inflammatory hyperpigmentation which are conventionally associated with the usage of lasers alone. So, higher fluences can be used for treatment with fewer chances of post-inflammatory hyperpigmentation.

GFC IN SKIN REJUVENATION (VAMPIRE FACELIFT)

Skin rejuvenation with autologous GFC demonstrated good results with an increase in skin homogeneity and patient satisfaction without serious side effects.

GFC enhanced gene expression of matrix molecules, such as collagen, and stimulates fibroblast proliferation ex vivo in the experimental models, thereby increasing total protein synthesis. GFC enhances elastin productivity by fibroblasts and stimulation of myofibroblasts.

GFC treatment increases the proliferation of human dermal fibroblasts, increases procollagen type I carboxy-terminal peptide production by human dermal fibroblasts, and increases expression of type 1 collagen. GFC can be directly injected into the skin. 

Skin remodeling can be enhanced by increasing penetration and inducing mild inflammatory reactions through the use of microneedles and lasers along with GFC.

GFC helps in the remodeling of the skin.

 

As an adjuvant to lasers or micro-needling, it is usually done in 3-4 weeks and the maintenance session is every 3 months. 

MN-RF with GFC

MNRF, i.e., Microneedling with Radio-frequency laser therapy combined with GFC resulted in objective improvement in the elasticity of the skin, a lower erythema index, and an increased density of collagen. Histologically, an increase in the length of the dermo-epidermal junction, and in the amount of collagen and fibroblasts, was seen in the treated skin.

GFC can be combined with Microneedling and Radio-frequency for the treatment of deep wrinkles and severely photodamaged skin. The combination helps in reducing transit adverse effects like erythema and decreases downtime, leading to rapid healing.

Under Eye Rejuvenation

GFC injections once a month for 3 months have shown good results for infraorbital rejuvenation, without any obvious adverse effects in a split-face blinded trial. It promotes an environment for vascularization, leading to a reduction in fine lines and an improvement in texture and complexion.

CONCLUSION

GFC therapy is one of the most upcoming forms of regenerative therapy with the potential to improve the homeostasis of the treated cells, and tissues, provided that harvesting standards are maintained. Since it belongs to one’s own body, safety is always ensured unlike various plant- and animal-derived stem cells or medications which may prove deleterious to the human body. 

The procedure is minimally invasive with down time of or two days. It